BULGARIAN NMR CENTRE
• Structural analysis and stereochemistry – structural analysis of small and medium size molecules – conformation and configuration; stereochemistry of compounds with central and planar chirality; new synthetic and natural biologically active compounds and mixtures - flavones, terpenoids, alkaloids, carbohydrates, antibiotics, nucleotides, etc.; steric interactions by 13Ñ NMR spectroscopy; structure and chemistry of phosphorus-containing compounds; structural analysis and oxidation stability of fats and oils - fatty acids and triacylglyceroles; linear and branched fluorescent polymers with application in optoelecrtonics.
• Molecular mobility – classic dynamic NMR, nuclear relaxation methods and gradient NMR spectroscopy; EXSY mixing time optimization; determination of exchange rate constants and thermodynamic parameters in complex multisite exchange system; DOSY; tautomeric and conformational equilibria; fluxtional isomerisation.
• Supramolecular aggregates and complexes – molecular recognition with cyclodextrines; structure and composition of surfactant solutions; determination of the critical micelle concentration; gradient NMR spectroscopy for drop size distribution analysis in food type emultions (water-in-oil and oil-in-water); colloid and water soluble polymers as drug delivery systems; mechanisms for drug immobilization in the polymer matrix.
• Computer programs for – automatic multiplets analysis; signal to noise enhancement in NMR spectra; determination of correlation times and activation energies of the overall and internal molecular reorientation; 13Ñ chemical shifts prediction for natural compounds using spectral databases.
Prof. Dr. Pavletta Shestakova
|Prof. Pavletta Shestakova, PhD, Head||209||136||psd|
|Prof. Nikolay Vassilev, PhD||112||172||niki|
|Prof. Svetlana Simova, DSc||104||140||sds|
|Assist. Prof. Alexander Kantardjiev, PhD||117||189||alexkant|
|Assist. Prof. Miroslav Dangalov, PhD||112||172||m.dangalov|
|Assist. Prof. Yavor Mitrev, PhD||106||146||yavor|
|Dessislava Gerginova, Phd student||103||120||dpg|