BULGARIAN NMR CENTRE

Research interests

Structural analysis and stereochemistry structural analysis of small and medium size molecules conformation and configuration; stereochemistry of compounds with central and planar chirality; new synthetic and natural biologically active compounds and mixtures - flavones, terpenoids, alkaloids, carbohydrates, antibiotics, nucleotides, etc.; steric interactions by 13 NMR spectroscopy; structure and chemistry of phosphorus-containing compounds; structural analysis and oxidation stability of fats and oils - fatty acids and triacylglyceroles; linear and branched fluorescent polymers with application in optoelecrtonics.

Molecular mobility classic dynamic NMR, nuclear relaxation methods and gradient NMR spectroscopy; EXSY mixing time optimization; determination of exchange rate constants and thermodynamic parameters in complex multisite exchange system; DOSY; tautomeric and conformational equilibria; fluxtional isomerisation.

Supramolecular aggregates and complexes molecular recognition with cyclodextrines; structure and composition of surfactant solutions; determination of the critical micelle concentration; gradient NMR spectroscopy for drop size distribution analysis in food type emultions (water-in-oil and oil-in-water); colloid and water soluble polymers as drug delivery systems; mechanisms for drug immobilization in the polymer matrix.

Computer programs for automatic multiplets analysis; signal to noise enhancement in NMR spectra; determination of correlation times and activation energies of the overall and internal molecular reorientation; 13 chemical shifts prediction for natural compounds using spectral databases.

Website

LABORATORY MEMBERS

Head:

Prof. Dr. Pavletta Shestakova


02 9606 136
209
psd@orgchm.bas.bg
Name Room Phone -mail*
Prof. Pavletta Shestakova, PhD, Head 209 136 psd
Prof. Nikolay Vassilev, PhD 112 172 niki
Prof. Svetlana Simova, DSc 104 140 sds
Assist. Prof. Alexander Kantardjiev, PhD 117 189 alexkant
Assist. Prof. Miroslav Dangalov, PhD 112 172 m.dangalov
Assist. Prof. Yavor Mitrev, PhD 106 146 yavor
Dessislava Gerginova, Phd student 103 120 dpg

Projects

Selected group publications(Q1)

2018

ChemSusChem, 11,
10,
1612-1616
Going Beyond the Limits of the Biorenewable Platform: Unprecedented Sodium Dithionite Promoted Stabilization of 5-Hydroxymethylfurfural
Food and Chemical Toxicology, 111,
605-615
New iridoids from Verbascum nobile and their effect on lectin-induced T cell activation and proliferation
Applied Catalysis A: General, 560,
119-131
Efficient solid acid catalysts based on sulfated tin oxides for liquid phase esterification of levulinic acid with ethanol.