LABORATORY ORGANIC SYNTHESIS AND STEREOCHEMISTRY

Research

The research interest in our department encompass several areas spanning synthetic organic and organometallic chemistry, and asymmetric catalysis. Specific areas of research focus on:

Synthesis of organometallic compounds and complexes of main group and transition metals in respect of their applications in organic synthesis. Rational design and synthesis of catalytic systems, including asymmetric metal-mediated and organocatalytic systems, based on readily available chiral sources. Efforts are focused on the development of new chiral ligands and reagents. NMR spectroscopy is used as tool for structure elucidation, investigation of the stereochemical course of selective transformations and configuration determinations.

Development of efficient and flexible routes for synthesis of multifunctional organic compounds intermediates, building blocks and target compounds possessing biological activity; compounds with fluorescent properties as new materials for development of organic light emitting diodes (OLEDs); calixarenes with phosphinoyl type ligating groups at the narrow rim.

Design and synthesis of functionalized cyanines using organometallic approaches.

Solventfree and microwave (MW) assisted synthesis of multifunctional chiral and non-chiral heterocyclic compounds.

Custom synthesis and process development synthesis work over a broad range of transformations is offered for customers. Projects planning and implementation are carried out under the strictest confidence.

Laboratory website

Laboratory members

Head:

Assoc. Prof. Dr. Svilen Simeonov


(+359 2) 9606 114
307
svilen@orgchm.bas.bg
Name Room Phone -mail*
Assoc. Prof. Svilen Simeonov, PhD, Head 307 114 svilen
Prof. Vanya Kurteva, PhD 309 156 vkurteva
Prof. Vladimir Dimitrov, DSc 306 157 vdim
Prof. Liudmil Antonov, DSc 316 125 lantonov
Assoc. Prof. Georgi Dobrikov, PhD 321 132 gmdob
Assoc. Prof. Irena Philipova, PhD 301 152 irena
Assoc. Prof. Kalina Kostova, PhD 311 158 kalina
Assist. Prof. Atanas Kourutus, PhD 302 102 ak
Assist. Prof. Ivailo Slavchev, PhD 321 132 ivaylo.slavchev
Assist. Prof. Mariana Kamenova-Nacheva, PhD 310 134 anmari
Assist. Prof. Maya Marinova, PhD 308 154 mm
Assist. Prof. Nadezhda Tabakova, PhD 314 101 tabakova
Assist. Prof. Vera Deneva, PhD 302 102 vera_deneva
Assist. Prof. Yana Nikolova, PhD 321 132 ynikolova
Assist. Irena Zagranyarska 311 158 irenash
Assist. Krasimira Dikova 311 158 petkova
Assist. Maya Tavlinova 308 154 maya
Assist. Zhanina Petkova 312 117 zhpetkova
Silviya Hristova, PhD student 302 102 hristowa.silvia
Boryana Petrova, chemist 310 134 bmp
Georgi Gerginov, chemist 307 114 ggerginov
Martin Ravutsov, chemist 312 117 mravutsov
Raina Todorova, chemist 420 183 reni
Simeon Angelov, chemist 320 anguelovsimo
Stanislava Todorova, chemist 309 156 stodorova
Yana Medarska, chemist 302 102

Projects

Selected group publications(Q1):

2018

Dyes and Pigments, 156,
91-99
A concept for stimulated proton transfer in 1-(phenyldiazenyl)naphthalen-2-ols
Dyes and Pigments, 157,
267-277
Bright green-emitting ds-DNA labeling employed by dicationic monomethine cyanine dyes: Apoptosis assay and fluorescent bio-imaging
Dyes and Pigments, 148,
452-459
New series of non-toxic DNA intercalators, mitochondria targeting fluorescent dyes
Dyes and Pigments, 158,
517-525
Cell penetrating, mitochondria targeting multiply charged DABCO-cyanine dyes
ChemSusChem, 11, 14,
2300-2305
Valorization of Oleuropein via Tunable Acid-Promoted Methanolysis
Chem. Rev.118,
10458-10550
Production and Synthetic Modifications of Shikimic Acid
J. Enzyme Inhib. Med. Chem. 33, 768-776
Novel hits for acetylcholinesterase inhibition derived by docking-based screening on ZINC database
ChemSusChem, 11, 10,
1612-1616
Going Beyond the Limits of the Biorenewable Platform: Unprecedented Sodium Dithionite Promoted Stabilization of 5-Hydroxymethylfurfural
Sep. Purif. Technol.
204, 328-335
Insights into the synergistic selectivity of 4f-ions implementing 4-acyl-5-pyrazolone and two new unsymmetrical NH-urea containing ring molecules in an ionic liquid
Food Chem. Toxicol.
118, 505-513
Prenylated ?-diketones, two new additions to the family of biologically active Hypericum perforatum L. (Hypericaceae) secondary metabolites
ChemCatChem, 10, 23,
5406-5409
Solvent?Free Catalytic Self?Etherification of 5?Hydroxymethyl Furfural