Research

The research interest in our department encompass several areas spanning synthetic organic and organometallic chemistry, and asymmetric catalysis. Specific areas of research focus on:

• Synthesis of organometallic compounds and complexes of main group and transition metals in respect of their applications in organic synthesis. Rational design and synthesis of catalytic systems, including asymmetric metal-mediated and organocatalytic systems, based on readily available chiral sources. Efforts are focused on the development of new chiral ligands and reagents. NMR spectroscopy is used as tool for structure elucidation, investigation of the stereochemical course of selective transformations and configuration determinations.

• Development of efficient and flexible routes for synthesis of multifunctional organic compounds – intermediates, building blocks and target compounds possessing biological activity; compounds with fluorescent properties as new materials for development of organic light emitting diodes (OLEDs); calixarenes with phosphinoyl type ligating groups at the narrow rim.

• Design and synthesis of functionalized cyanines using organometallic approaches.

• Solventfree and microwave (MW) assisted synthesis of multifunctional chiral and non-chiral heterocyclic compounds.

• Custom synthesis and process development – synthesis work over a broad range of transformations is offered for customers. Projects planning and implementation are carried out under the strictest confidence.

Laboratory members

Head:

Prof. Dr. Svilen Simeonov

(+359 2) 9606 114

307

svilen@orgchm.bas.bg

Name	Room	Phone	Е-mail*
Prof. Svilen Simeonov, PhD, Head	215/307	199/114	svilen.simeonov
Prof. Vanya Kurteva, PhD	309	156	vanya.kurteva
Prof. Vladimir Dimitrov, DSc	306	157	vladimir.dimitrov
Assoc. Prof. Atanas Kourutus, PhD	314	101	atanas.kurutos
Assoc. Prof. Vera Deneva, PhD	302	102	vera.deneva
Assoc. Prof. Georgi Dobrikov, DSc	321	132	georgi.dobrikov
Assoc. Prof. Irena Philipova, PhD	301	152	irena.filipova
Assoc. Prof. Kalina Kostova, PhD	311	158	kalina.kostova
Assist. Prof. Zhanina Petkova, PhD	312	117	zhanina.petkova
Assist. Prof. Ivailo Slavchev, PhD	321	132	ivaylo.slavchev
Assist. Prof. Irena Zagranyarska, PhD	311	158	irena.zagranyarska
Assist. Prof. Krasimira Dikova, PhD	311	158	krasimira.dikova
Assist. Prof. Mariana Kamenova-Nacheva, PhD	310	134	mariana.nacheva
Assist. Prof. Martin Ravutsov, PhD	312	117	martin.ravutsov
Assist. Prof. Maya Marinova, PhD	308	154	maya.marinova
Assist. Prof. Maya Tavlinova-Kirilova, PhD	308	154	maya.tavlinova
Assist. Prof. Nadezhda Tabakova, PhD	314	101	nadezhda.tabakova
Assist. Prof. Plamena Staleva, PhD	314	101	plamena.staleva
Assist. Hristo Petkov	307	114	hristo.petkov
Raina Todorova, chemist	420	183	raina.todorova
Stanislava Todorova, chemist	309	156	stanislava.todorova

Projects

Selected group publications(Q1):

2018

Dyes and Pigments, 156,
91-99

A concept for stimulated proton transfer in 1-(phenyldiazenyl)naphthalen-2-ols

Dyes and Pigments, 157,
267-277

Bright green-emitting ds-DNA labeling employed by dicationic monomethine cyanine dyes: Apoptosis assay and fluorescent bio-imaging

Dyes and Pigments, 148,
452-459

New series of non-toxic DNA intercalators, mitochondria targeting fluorescent dyes

Dyes and Pigments, 158,
517-525

Cell penetrating, mitochondria targeting multiply charged DABCO-cyanine dyes

ChemSusChem, 11, 14,
2300-2305

Valorization of Oleuropein via Tunable Acid-Promoted Methanolysis

Chem. Rev.118,
10458-10550

Production and Synthetic Modifications of Shikimic Acid

J. Enzyme Inhib. Med. Chem. 33, 768-776

Novel hits for acetylcholinesterase inhibition derived by docking-based screening on ZINC database

ChemSusChem, 11, 10,
1612-1616

Going Beyond the Limits of the Biorenewable Platform: Unprecedented Sodium Dithionite Promoted Stabilization of 5-Hydroxymethylfurfural

Sep. Purif. Technol.
204, 328-335

Insights into the synergistic selectivity of 4f-ions implementing 4-acyl-5-pyrazolone and two new unsymmetrical NH-urea containing ring molecules in an ionic liquid

Food Chem. Toxicol.
118, 505-513

Prenylated ?-diketones, two new additions to the family of biologically active Hypericum perforatum L. (Hypericaceae) secondary metabolites

ChemCatChem, 10, 23,
5406-5409

Solvent?Free Catalytic Self?Etherification of 5?Hydroxymethyl Furfural